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Other examples include the use of Cannabis with LSD, where the active chemicals in cannabis enhance the hallucinatory experience of LSD-use, reducing the risk of a "bad trip".Īn example of negative effects of synergy is if more than one depressant drug is used that affects the Central Nervous System (CNS), for example alcohol and Valium. This is often seen with recreational drugs, where 5-HTP, a Serotonin precursor often used as an antidepressant, is often used prior to, during, and shortly after recreational use of MDMA as it increases the "high" and decreases the "comedown" stages of MDMA use. This is sometimes exploited in combination preparations, such as Codeine mixed with Paracetamol to enhance theĪction of codeine as a pain reliever. More accurately known as emergent behavior ĭrug synergism occurs when drugs can interact in ways that enhance or magnify one or more effects, or side effects, of those drugs. Behavior of whole systems unpredicted by the behavior of their parts taken separately.A dynamic state in which combined action is favored over the sum of individual component actions.A mutually advantageous conjunction where the whole is greater than the sum of the parts.In the 1960s it was first used to describe supposed economies of scale in business, reappearing in the 1990s as a common business buzzword. The term began to be used in the broader, non-theological, sense by 1925. Synergism stems from the 1657 theological doctrine that human will cooperates with divine grace in regeneration. The opposite of synergy is antagonism, the phenomenon where two agents in combination have an overall effect which is less than the sum of their individual effects. Synergy or synergism (from the Greek synergos meaning working together, circa 1660) refers to the phenomenon in which two or more discrete influences or agents acting together create an effect greater than the sum of the effects each is able to create independently.